Sodium thiosulfate is used to treat a fungal infection of the skin called tinea versicolor. Sodium thiosulfate is used to reduce iodine back to iodide before the iodine can complex with the starch to form the characteristic blue-black color. In the mining of gold sodium thiosulfate is an important component. It is also used in the extraction of gold. Calciphylaxis is vasculopathy characterized by ischemia and painful skin necrosis due to calcification and intimal fibroplasia of thrombosis of the panicular arterioles. It may be given to you for other reasons. The medical uses of sodium thiosulfate include treatment of cyanide poisoning and pityriasis. This is . However, it scavenges less oxygen than sodium sulfite. If you get Sodium thiosulfate lotion in your eyes, immediately flush with cool tap water. . Adult: To be given after 300 mg of sodium nitrite has been admin over 5-20 min: 12.5 g of sodium thiosulfate (50 ml of a 25% solution or 25 ml of a 50% solution) given over 10 min. Use of sodium thiosulfate in the treatment of calciphylaxis has been described primarily in case series and case reports and in a single retrospective review, it demonstrated beneficial effects in most patients, with partial to complete resolution of skin lesions and reductions in radiotracer activity on bone scans. Sodium thiosulfate (STS) (Na 2 S 2 O 3) is used to prevent and treat cyanide poisoning ( 7 ). Sodium thiosulfate administered by the topical route can enable the treatment of any ectopic calcification, whatever its origin. Follow the directions on the prescription label. It is a multi-purpose chemical used in several applications such as in metal refining, photography, gold mining, as an anti-chlorine agent, and an antioxidant. By Posted westside harp stability In best candle warmer for bath and body works It is typically found in its pentahydrate form which is either white in colour, or colourless altogether. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of eye contact (irritant), of ingestion, of inhalation. It is used as a cleansing agent. Sodium thiosulfate, which is also referred to as sodium sulphate, is a chemical compound which has the formula Na 2 S 2 O 3. Salicylic acid helps your skin absorb the sodium thiosulfate. A chemical that reacts with excess chlorine used for purification, disinfecting, or some other purpose. It has since been approved for the treatment of certain rare medical conditions. Is Sodium thiosulfate bad for my skin? First-aid measures Eye ContactRinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Current treatment modalities used to counteract this pathology are not entirely effective. Intravenous sodium thiosulfate has been used successfully to treat calciphylaxis and tumoral calcinosis in patients who are undergoing renal dialysis. Talk with your doctor before you use any other medicines or cleansers on your skin. Salicylic acid and sodium thiosulfate topical (for the skin) is a combination medicine used to treat a skin infection called tinea versicolor, that appears as white patches. The reaction of sodium thiosulfate and hydrochloric acid generates sulfur dioxide gas, which is a skin and eye irritant. The drug eliminates the unpleasant allergic manifestations, cleanses the skin, facilitates breathing, improves the work of the digestive system. Sodium thiosulfate (Na2S2O3) can be used to neutralize or remove residual chlorine. 6-10 The treatment is generally considered to be safe, 11 with minimal adverse effects other than occasional nausea. 800-424-9300 CHEMTREC (USA) 613-996-6666 CANUTEC (Canada) 24 Hours/Day: 7 Days/Week 3/4/2003 5/3/2004 . Depending on the medical condition being treated, the salt can be injected, taken orally, or applied to the skin. This pentahydrate of sodium thiosulfate is described by the following chemical formula: Na 2 It is used in several pharmaceutical preparations. S Karthik, A Bhatt, 1 and T Babu Author . It is also available as its pentahydrate salt (Na 2 S 2 O 3 .5H 2 O), with a molar mass of 248.18 g/mol. According to Strazzula et al: "The mechanism of sodium thiosulfate in the treatment of calcium-related disorders is thought to be multifactorial. Salicylic acid helps your skin absorb the sodium thiosulfate. . Skin Contact: Wash skin with soap and plenty of water for at least 15 minutes. It is also a topical anti-fungal such as can be used for ringworm. Salicylic acid helps your skin absorb the sodium thiosulfate. To make the 10% ST solution, just add 10 grams Sodium Thiosulfate to 90 grams (ratio 1:9) of water and you will have the 10% solution so you can use drops if you want. SDS NUMBER: EUSA-150 CURRENT ISSUE DATE:January, 2022 Page 5 of 7 SODIUM THIOSULFATE POTENTIAL HEALTH HAZARDS ACUTE EFFECTS OF EXPOSURE: SKIN: Dust, solutions or mist may cause skin irritation from repeated or prolonged contact. May cause eye, skin, and respiratory tract irritation. Sodium thiosulfate also used in leather tanning. It often manifests with skin necrosis. Slightly hazardous in case of skin contact (irritant . Uses and Benefits of Sodium Thiosulfate Sodium thiosulfate is a powerful detoxing agent to remove mercury and other heavy metals from the body. 3,8,9 The use of high bicarbonate dialysate may resolve sodium thiosulfate-induced metabolic acidosis.8 Because each 25 g of sodium thiosulfate in 100 mL of normal saline contains 4.8 g of sodium, the sodi um load should be considered; increases in serum sodium Abstract: The invention provides a source of sodium thiosulfate via the dialysate used to cleanse the bool of toxic and metabolic waste in the patients undergoing hemodialysis, peritoneal dialysis, or gastro-intestinal dialysis for treatment of end-stage or near end-stage chronic renal disease. Talk with your doctor before you use other drugs or products on your skin. In case of large amount of chemical ingestion or inhalation, it can be hazardous. Sodium thiosulfate has many roles including being used as an antidote to cyanide poisoning as well as an antifungal drug. Sodium thiosulfate is an antifungal medicine that fights infections caused by fungus. An exothermic reaction gives off heat, like our hot pak. The painful skin ulcers improved significantly soon after treatment, with a slight reduction in the calcium-phosphorus product. Sodium thiosulfate anhydrous 7772-98-7 100 Toxicological Data on Ingredients: Sodium thiosulfate anhydrous LD50: Not available. Sodium thiosulfate is an antifungal medicine that fights infections caused by fungus. Since it is employed as a EYES: Dust, solutions or mist may irritate or burn the eyes and cause temporary conjunctivitis. Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. It is used as an antidote for cyanide toxicity by increasing the rate of detoxification of cyanide by the enzyme rhodanase. Sodium thiosulfate (STS) is an industrial chemical which also has a long medical history. Salicylic acid helps your skin absorb the sodium thiosulfate. It is used in photographic film processing. He was completely devoid of scalp and body hair (alopecia totalis); had salt and pepper like appearing skin over back and legs; pinched nose; thick and tight skin in hands and feet. MSDS Name: Sodium thiosulfate Catalog Numbers: AC202870000, AC202870010, AC202870025, AC202870050, AC202875000, S75222, S78930-1, S78930-2, S78930-3, S78930-4, S79809, NC9417189, . Salicylic acid and sodium thiosulfate topical (for the skin) is a combination medicine used to treat a skin infection called tinea versicolor, that appears as white patches on the skin. Incompatible products. Case Reports/Series Dialysis Patients Sodium thiosulfate is an antifungal medicine that fights infections caused by fungus. It demonstrated beneficial effects in most patients, with partial to complete resolution of skin lesions and reductions in radiotracer activity on bone scans. The medical uses of sodium thiosulfate include treatment of cyanide poisoning and pityriasis. These are in a 2:1 ratio. Reply 4 Cyanide Poisoning, Heavy Metals, Liver Poisoning Posted by Ted (Bangkok, Thailand) on 09/16/2007 383 posts Exposure to moist air or water. Be sure to use Sodium thiosulfate lotion for the full course of treatment. To do this, we dissolve sodium carbonate in. Sodium thiosulphate is a non-toxic chemical but can cause slight irritation on exposure to skin and eyes. In addition, sodium thiosulfate acts as a reducing agent or antioxidant, which neutralizes free radicals. Salicylic acid and sodium thiosulfate topical (for the skin) is a combination medicine used to treat a skin infection called tinea versicolor, that appears as white patches on the skin. The skin over his . Safety issues What is the risk of sodium thiosulfate? Formula and structure: The chemical formula of sodium thiosulfate is Na 2 S 2 O 3 and its molar mass is 158.11 g/mol. Sodium thiosulfate is a reducing agent. . Sodium thiosulfate is an antifungal medicine that fights infections caused by fungus. First Aid Procedures: . Research in this field has been limited by a paucity of samples due to the rarity of the disease. In addition, Sodium thiosulfate is used in calciphylaxis in hemodialysis patients with end-stage kidney disease. Uses of Sodium Thiosulfate It is used as an antidote to cyanide poisoning. If a poisoning or overdose occurs, get emergency help. To such signs, indicating the development of the early stage of psoriasis, refers to the appearance on the skin of unusual seals . How does sodium thiosulfate neutralize chlorine? This type of poisoning can occur if you are exposed to smoke from a house or industrial fire, if you swallow or breathe in cyanide, or if you get cyanide on your skin. Use of sodium thiosulfate in the treatment of calciphylaxis has been described primarily in case series and case reports. In the method of the invention, dialysis solution . However, for prophylactic purposes for example, to prevent the occurrence of an allergic reaction, thiosulfate is useless. Get medical aid if irritation develops or persists. Sodium thiosulfate is an important inorganic salt with several medical uses. The dose may be 2 ml of 0.17 M (a solution of 4 ml 10% sodium thiosulfate and 6 ml sterile water for injection). Do not treat a poisoning or overdose yourself. For the process of tanning in the leather industry, sodium thiosulfate is used. It has a NFPA Rating of 1,0, 0 for health, fire and reactivity, respectively. INHALATION: Inhalation of product dust or mist may irritate the . Drug interactions are reported among people who take Sodium thiosulfate and Venofer. To investigate whether the reactivity difference between the 2 gold salts was due to differences in bioavailability, some experiments were carried out. It is a calcium-chelating agent and has many medical uses in removing toxic substances from the body. Skin ContactWash off immediately with plenty of water for at least 15 minutes. It is used as a preservative to prevent dried fruit from discoloring, and for preserving meats, and is used in the same way as sodium thiosulfate to convert elemental halogens to their respective hydrohalic acids, in photography and for reducing chlorine levels in pools. Fowler later initiated the use of 0.5% w/w gold sodium thiosulfate (GSTS) in petrolatum as a test preparation to determine the presence of contact allergy to gold. . Salicylic acid and sodium thiosulfate topical (for the skin) is a combination medicine used to treat a skin infection called tinea versicolor, that appears as white patches on the skin. Sodium Thiosulfate, Anhydrous Hypo: Sodium Hyposulfate SX0820 Analytical reagent. The phase IV clinical study analyzes what interactions people who take Sodium thiosulfate and Venofer have. Sodium thiosulfate dose in the Management of delayed calcium extravasation (calcinosis cutis) (off-label): IV: 12.5 g over 30 minutes; may increase the dose gradually to 25 g 3 times per week; monitor for non-anion gap acidosis, low calcium, and severe nausea. Sodium Thiosulfate, Anhydrous Sodium Hyposulfite, Anhydrous O7772-98-7 Na 2 S 2 3 98.5 Trade Secret Statement: Not applicable. Common concerns See how this product scores for common concerns. Find patient medical information for sodium thiosulfate intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Sodium Thiosulfate trade name is Sodium Thiosulfate, Na2S2O3.5H20 and it's a white crystalline product. Sodium thiosulfate is to be administered only by or under the immediate supervision of your doctor. If you have an allergy to sodium thiosulfate or any other part of sodium thiosulfate. LC50: Not available. Sodium thiosulfate dressings facilitate healing of refractory cutaneous ulcers of calcinosis cutis. Get medical attention immediately if symptoms occur. Abstract. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may . Wash clothing before reuse. Indications for the use of sodium thiosulfate in psoriasis are the appearance of the first signs of the disease, which indicate that the defenses of the patient's body are reduced, and the disease is actively coming. The authors thank the Skin and Allergy Research Unit at Chulalongkorn University . Fungal infections of the skin [ edit] Foot baths of sodium thiosulfate are used for prophylaxis of ringworm. What is the purpose of adding sodium thiosulfate? Methaemoglobin concentration should not exceed 30-40%. Wash, rinse and dry the affected areas before applying this medicine. Calciphylaxis is an obliterative vasculopathy that causes ischemia and necrosis of the skin, subcutaneous fat, visceral organs, and skeletal muscle. sodium thiosulfate is used. It is also called sodium hyposulfite or 'hypo'. To neutralize 1 liter of a 200 ppm chlorine solution, approximately 0.4 - 1.4 grams of sodium thiosulfate would be required. SODIUM THIOSULFATE (SOE dee um thi oh SUHL feyt) is used to treat cyanide poisoning. Sodium thiosulfate (STS) was used for treatment in this case. May be hazardous in case of inhalation. Remove contaminated clothing and shoes. Sodium thiosulfate is a relatively non-toxic substance. If you use Sodium thiosulfate and salicylic acid too often, your skin problem may become worse. Medical uses of Sodium thiosulfate Patrick L. McGeer*, Edith G. McGeer and Moonhee Lee Kinsmen Laboratory of Neurological Research, University of British Columbia, VancouverBC V6T 1Z3, Canada Background Sodium thiosulfate (Na 2 S 2 O 3, STS) is an industrial compound which has a long history of medical use. A range of approximately 2 to 7 parts sodium thiosulfate to neutralize one part chlorine is generally suggested. ABSTRACT: The use of sodium thiosulfate has emerged as a promising treatment for calciphylaxis, albeit inconclusively in terms of efficacy and variable outcomes. LOW Cancer LOW Allergies & Immunotoxicity LOW Developmental and Reingredientive Toxicity LOW Use Restrictions Ingredient concerns CONCERNS DATA SOURCES Products with this Ingredient Multiple, additive exposure sources Data gaps Ecotoxicology It is also used in some vital tests for kidney . . It simply reacts and forms sodium hydrogen sulfate or sodium bisulfate which is an inactive . It . Wash your hands before and after use. Wash skin with soap and plenty of water for at least 15 minutes. Common interactions include dry skin among females. Sodium thiosulfate, 0.1 N standard solution Revision Date 24-Dec-2021 Conditions to Avoid Excess heat. What do I need to tell my doctor BEFORE I take Sodium Thiosulfate? Incompatible Materials Acids Hazardous Decomposition ProductsSulfur oxides, Sodium oxides Hazardous Polymerization Hazardous polymerization does not occur. Sodium sulfite (sodium sulphite) is a soluble sodium salt of sulfurous acid . For our purposes in the pool, sodium thiosulfate is used to reduce the amount of chlorine. 2013;6(5):41-44.) Sodium thiosulfate is a skin, eye, nose and throat irritant. Shake well and apply a thin layer of lotion to cover the affected skin and surrounding area. InhalationRemove to fresh air. Subsequently it proved to be effective in treating calcium-mediated disorders. 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