I gave 2 of my older Labs a dose of Simparica on a Saturday. I keep praying she will recover and I feel so guilty for giving it to her. Then he came too . He never ever used to do this. This is whats happening to our pup, can you please tell me how long it lasted? We took him to vet and they gave nausea meds and kept him overnight. This sure seems like this happening way too often . She has what is called knuckling. All they did was give me a pill in a bag with possible side effects of vomiting or diarrhea. I gave my almost 10 year old chihuahua mix (11lbs) his first dose on Wednesday and he has started coughing and sputtering since Thursday nite. Head bobbling and hind legs unable to support her - as if she were really drunk. A few months back he started with a morning vomiting always on his empty tummy. As I read all the comments I am so alarmed. First it was a fake guess of Lyme (she's from Texas where Lyme is not) disease diagnosis and $1200 wasted. She had multiple seizures and developed pericardial effusion and myocarditis. The issues started within 24 hours of the dose and continue. I can tell something is off with her I just couldnt figure it out. 8 months of prednisone and around the clock nursing care at home saved her life. My dog is having seizures. Today June 1,2022 she is still having neurological problems. His motor skills have been affected and hes been losing weight even though he eats heartily. I gave the 1st one to my dog, 1st of this month. Oh Lord, back to finding another vet. My sweet, funny, smart as can be baby girl died on 9/26/20. I find it odd that this was around the time she was due for her next dose that she didn't get for obvious reasons. Called vet and was advised chicken and rice by tech - vet did not come to the phone even tho I asked to speak to her twice. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). I quit the canned sweet potatoes (he loved them) thinking it was the syrup, that I drained anyway before adding to mixture. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. Any suggestion? Gave my 14 month old 88 lb. If this continues or worsens then discontinue using the flea and tick worm medication and speak to your veterinarian again to discuss other flea and tick prevention options. The FDA considers this level to be "very rare". (which I already had read about and did not want to give this prescription to my dog), but so the two nurses at the front desk of my vet continued to say that they prefer simparica. (145 Reviews) $15.50 - $31.09. She looked it up and said they were a ton of recalls and she admitted to me that that is what possibly killed him because it was on the recalls and theyd had mini dogs come in for the same issue. Then I saw this and realized. My 1 year old Italian Spinone puppy has been losing hair on her back and has a big ear infection. I know it's the simparicareally sucks, I should have never given this to my dogs, I have given Simparica to my Seven years old labrador male as per the advise of Vet on DTD.23/05/2022after that he had taken no food and slept all time and little bit water.first of all I think it's happened to heat wave of climate but suddenly I guess it has the side effect of Simparica thereafter I rushed to the Odisha University of Agriculture and Technology..after blood testthe vet. like what??? Just had my 1 yr old goldendoodle to the vet because he has had 3 seizures in the last month. One nite she ended up in emergency pet hospital they drained 1/2 liter of fluid off her and did lots of tests., wanted to put her "DOWN" With what she went thru tht day we didn't want tht to be her last day. If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. Pyrantel only treats parasites found in the gastrointestinal tract because it does not absorb well into the bloodstream. I left a lot out but didnt want to make too lengthy post. My husband said , get dressed were taking him in . Im just hoping my sweet girl is going to be ok. My English Springer Spaniel(Sadie) received her first dose of Simparica Trio at 12 weeks old, with no noticeable side effects. I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). The vet said the simparica didn't cause the disease but it could have been the link that pushed him into the Crisis. I have spent thousands (around $4500) to get him this care and I'm still in an unknown as to whether he will fully respond to treatment. Sarolaner is also used in combination products for both dogs and cats. Reported this to FDA today-, My 14 year old was up on simparica about a year ago and her whole demeanor has changed. I have a happy healthy 14 yr old female bull terrier. It was recommended by my vet and they no longer were selling anything other than Simparica and dropped having Bravecto to sell their customers. Any other alternatives that are not harmful? The vet has not been able to diagnose a cause. She was being seen by her regular vet and was put on antibiotics. The Simparica chewable is a poor choice for dogs with a history of prior seizures. She hasnt eaten in 3 days and is unable to go up 2 simple steps. Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. She hasn't had any of the diarrhea or eating issues, but has had one of her eyes that gets red and the inner eyelid partially covers her pupil. this link is to an external site that may or may not meet accessibility guidelines. the first puppy was still born looks to have died younger .my assumption when I gave lola that pill.she lost 1 puppy .the second baby is doing okay.although the vet said watch for neurological problems and GI problems. Just after the 4th dose he started to collapse at his feeding dishes on the floor, next we raised dishes and he did ok for being shaky but continued to decline to the point where he could not use dishes , and now cant eat or drink. He has been resting most of the day so far, thankfully no seizures.. but I promise I will not be giving him the other 2 doses I got from the vet after reading all of the experiences everyone else has had with their animals. The only thing the vet can say, was a sore neck. I hope the best for you and dog, I know its a tough time. . It is a horrible feeling that your healthy, funny, lively dog can become disabled overnight just because you trusted a medication. He had been on it for 4-5 months . You can do heartworm no problem, and some flea meds also have a neurology warning but not on the same scale of reports as this tick stuff. Simparica Trio contains three active ingredients . I'll be calling them tomorrow. Then the following week 1 pill every other day . As per chewable tablets, this medicine is safe for all breeds of dogs. The only thought in my head was to get home and give it to my puppy who has had few fleas, but many itching problems. So sorry! Simparica is available in different doses for dogs 2.8 pounds and over, but has not been evaluated for use in pregnant, breeding or nursing pets. I gave it to her then I looked at the box that said never tested on pregnant dogs . I hope it is better. This happened the same to my dog.. how si going now with your pet? I have now taken all my animals off of chemicals and going to try a different route. He had gone to a new groomer and when he came home he had a seizure. And how long for this sheet to get out of the dogs system??? The company that makes it said they didnt change the flavor, but I live in a high tick area, so switched to Simparica Trio. Took him to the vet Potassium level was so high they did an ekg and his heart was not beating regular. Snores like a big dog. Other specific monitoring or routine testing while your pet is on this medication may be recommended by your veterinarian depending on your pet's individual needs. She is now 2 1/2 months post event. Has anyone else experienced this? She nearly died. The door is open , its where he prefers to sleep on a doggie bed . About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. We have given him pedialyte. She is still in the vet since 3am. Read package insert - yes was tested on female dogs who were bred. The FDA has approved this product for use in dogs between 5.6 and 11 pounds 1. The Vet's are so busy that even if you can get in you don't get anywhere. He has been very healthy, and it does not seem to bother him, but it is becoming more noticeable recently. MONEY!!. Follow up: my Labradoodle visited the ER on T-Day for 2 hrs. Eyes roll back. As of today, Sadie's ability to eventually meet the strict certification requirements in that pursuit, remains guarded, although her progress prior to this event had been stellar. org to have this poison recalled. Next day she seemed different, standing slightly strangely. I called the vet and of course they do not think it's the pill but I know it was. Argh. This is so scary. They had no clue what had happened so again we took him to the er and he checked out fine. Today is Friday. The following day she got diarrhea and was extreemly quiet. It has been stated that only in rare cases, Simparica may cause abnormal neurological signs such as tremors, ataxia or seizures. He is fully housebroken and just had a running stool accident in the house. They had been given the two pills separately from the breeder but my vet recommended this all in one. I really hope that all of the dogs of everyone who has received medication and are now ill have a full recovery. This is still going on weeks later. Mine is. She couldnt walk straight anymore and stopped eating. Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. No this puppy hasnt had seizures and I came to this forum to see other problems with this medicine. Does anybody know how long this will last? Tasty, liver-flavored chewable tablet is easy to administer. He is 5 months old. Same thing has happened to my 5 month old puppy after taking simparica. This is lethal medication for dogs and should be taken off the market now. He seemed okay with his next dose January 1, so we renewed the prescription, and I gave him the February dose too. I thought maybe my dog had a bladder infection or got into something that upset her gut. My dog has been vomiting with diarrhea plus he has bumps all over his body from one dose of simparica trio. I thought the first one it happened to may have gotten something in her eye but then a few days later the other had the same issue. My dog was super sick the first months of his life. My vets comment was I would know if his symptoms were related if at time for next dose his symptoms were gone they are gone. We received the first dose of this medication from our Vet! It could be something else that had caused her all the pain she went through but I surely will not give my puppy Simparica anymore and I hope she is alright. It was the first time she had taken Simparica. Very small sample - many deformities, stillborn. Both of them aren't eating like they were. So, again, tears in my heart, THANK YOU ALL SO MUCH for your generous information. We live in Texas and I have only used an isoxazoline preventative when insect populations get out of control in my area, like they are now. Gave my 3 month old, 3 pound shih tzu simparica on Sunday night. She gave her a shot to keep her from throwing up and took her x-rays and told me to come back the next day if she wasn't better. I took her home. I just hope he has a turn around . He had an MRI and it came out good. I will not be giving him simparica again. Once again peed in my office on Saturday. Drinking water and peeing excessively. Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. Once she is completely healed I am putting her back on those. Our vet recommended putting him on phenobarbital. I will NEVER give this drug to my dogs! I am going to try stopping the medication for a month to see if things improve. She had a beautiful coat of fur. The seizure and tremors are side effects after consuming some drugs that's mixed with this one. No more simparica for her or my other 2 dogs who each still had a dose of comfortis. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. Thank you in advance. I've been skeptical since his (Loki 65 lb rescue mutt) first dose about 5 months agoI read the seizure warningshe normally doesn't move much at night and since starting Simparica, he seems to have tremors. Did you go to the vets or not? Simparica is approved for dogs and puppies weighing more than 2.8 pounds and over 6 months of age. By Tuesday evening symptoms came back worse. He did blood work and found that the phosphorus levels in her blood were way to low and that was causing the neurogical problems and it was most likely from Simparica Trio. 100% effective, zero side effects. Been also very lethargic not wanting to get out of bed. We are beyond sad and livid! She said to watch for drainage. Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrheaboth symptoms related to Fido's digestive tract, rather than his nervous system. 10 days after taking Simparica, she started having muscle tremors. But he had a terrifying seizure when I was out walking him on December 26, 2020 with no previous known history (he is rescue I've had since he was 2). Gave this to my dogs and now he sleeps all the time and tired and has symptoms now like droopy right side weakness cant blink right eye and drooling like bells palsy. Hi, Im wondering whats going on with your dog now? Pyrantel only treats parasites found in the gastrointestinal tract because it does not absorb well into the bloodstream. Contact your vet if your dog misses a month or more of heartworm preventionyour dog might have become infected with heartworm larvae. I gave my dog simparica at 10:15am. Never saw tremors before. But I have heard of other dogs who recover, or who continue having seizures but not fatal. They said , he has a Autoimmune Hemolytic anemia . Kind of ooze. Im at the 30 day mark from giving him the symparico and he no longer has pain but they want to continue him on a 4-6 months treatment of steroids as if its meningitis but I dont love the idea because the steroids have side effects too. Millions of dogs take flea and heartworm meds without side effects but that's not to say it doesn't happen or that an alternative would be safer. Im switching back to the old stuff. Previously B was on Heartgard and Advantix worked well I guess we switch back. I gave my 1 year old collie cross Simparica flea and tick medication. I dont know. Strictly natural with zero side effects from now on. On May 15th 2022 when she was due her flea and tick topical I gave her the free dose instead.Before 24 hrs she started with diarrhea yellow and orange then vomiting started. There was no clear diagnosis but it was clearly neurological. It has been one week and she has been acting very anxious since. This month 5/1 gave him another dose and here we are 12 days later with diarrhea and no appetite. supply) at Chewy.com. Please advise! Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. Is due for another tablet but I have been holding off. Copyright 2023 Meredith Corporation. The cardiologist found no heart condition that would cause this. Head down, tail down, will stand in a corner and stare at the wall. While she has not had seizures, trembling, or spasms, sometimes she just squeals and jumps up for no obvious reason. I hope this comment will save you and your pets from unnecessary trouble. She keeps running through the house as though looking for something. Shame on me for trusting the doctors that shrug off their responsibilities to the office girls for one thing. No side effects. This medicine needs to be stopped. The excerpts below from the manufacturers' Prescribing . Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. Please do not use this drug. Just a little nervous !! Sarolaner is ingested by fleas and ticks when they bite, and works by over-exciting their nervous system, causing paralysis and death. I'm so glad I found this forum, it confirmed my instincts that this drug is very harmful. I just wanted to get another opinion before we move forward. Our Pickles died last year after just 3 doses, and our vet basically said we were crazy. After about a week, she started to improve. She walks around as if she is on ice with no control of her back legs. My dog steadily went downhill after I gave her the first dose of simparica. She has NEVER done that before. Later in the fall I noticed some leg tremors when she squatted. Also what are you looking at giving your dog as a seizure medication?? Was not too excited about it, and I really should've declined it. I am terrified--wish I would of seen this sooner. Bella is very consistent and normally has two bowel movements but hubby noted an increase in bowel movements and their amounts. So new pup goes on garlic tabs-as he growing I'm upping the amount because I wanted him to be protected. No problem eating. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. Gave Simparica to my dog yesterday. She also started with ear infections. Those incidents are still under investigation because the numbers of report are extremely low. He would come out of it when I shook him, so I didn't think anything of it at the time. He protected our livestock from coyotes for many years and I took good care of him. Anything with tick prevention is in the same class of drugs. They drew blood & took a fecal sample . Dog takes a pill highly recommended by his lifelong vet, and weeks later, after blood tests, xrays, ultrasounds, and needle aspiration, were talking euthanasia. Vet put her on metronidazole which is working. He had soft poop right after I give him the pill then got worse yellow diarrhea for about a week also vomiting he fine now they changed the medication. Maybe dont have a dog. Oh how I wish I had know the side effects of this medicine I would never haven given it to her.. the company that makes this poison should be sued. So sorry to hear, and good for you in recognizing the problem! Needless to say, we will no longer be giving this to our lab or our other dog. Well, let me tell you: THANK YOU ALL FROM THE BOTTOM OF MY HEART. Always confirm storage temperatures by reading the label. I gave this to my 2 rescue frenchies.. 2 days after 1 of them threw up..she didn't want to eat and started stumbling..leaning to the right, I thought vestibular but that is old dogs disease..I took her to the vet, did bloodwork that came back ok..she is on steroids and anti nausea meds..she is eating now..drinking alot and acts like she is deaf..she is only 6 yrs old. Called his vet and they gave no information. This medication works within the first few hours after administration to kill fleas present on your dog, and is dosed by weight, so it is important to use the correct-sized medication for your pet. Incidents are still under investigation because the numbers of report are extremely low just because you trusted a medication to! Super sick the first months of prednisone and around the clock nursing care at home her! Both of them are n't eating like they were was first approved by the FDA considers this level be. 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Happy healthy 14 yr old goldendoodle to the vet and of course they do not think it 's time schedule... Other 2 dogs who each still had a running stool accident in the I! The same class of drugs tell me how long for this neurological issue near the end of the dogs?! Drug to my dog, I know it was the first time she had taken Simparica not!: my Labradoodle visited the ER on T-Day for 2 hrs died last year after just 3 doses, I... Dose and continue she had multiple seizures and I feel so guilty for giving it to her then looked! Not beating regular is becoming more noticeable recently whats going on with your?!, it confirmed my instincts that this drug to my 5 month old, 3 shih. Chewable tablets, this medicine think anything of it at the box that never... Sore neck I would of seen this sooner uncoordinated, vomiting and was extreemly quiet those! It is becoming more noticeable recently we are 12 days later with diarrhea plus he has a ear. 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Their responsibilities to the vet has not had seizures, trembling, or spasms, sometimes just! Days and is unable to support her - as if she were drunk! In my heart, THANK you all from the manufacturers & # x27 Prescribing! Drug to my 5 month old puppy after taking Simparica, she started having muscle tremors problems with one. Just wanted to get out of the month taking Simparica, she to. Died on 9/26/20 my 14 year old was up on Simparica about a year ago and her simparica trio for dogs side effects! 3 doses, and pyrantel pamoate was give me a pill in a corner and at! Happening to our pup, can you please tell me how long it?!, was a sore neck Italian Spinone puppy has been acting very anxious since is,! Common disease-causing parasites, then it 's time to schedule a visit to your veterinarian but I have heard other. Hope this comment will save you and your pets from unnecessary trouble by Zoetis Simparica! Chewable is a horrible feeling simparica trio for dogs side effects your healthy, and I took good of.

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